Insensitivity of cerebral oxygen transport to oxygen affinity of hemoglobin-based oxygen carriers
نویسندگان
چکیده
منابع مشابه
Hemoglobin-based oxygen carriers
Transfusable fluids that may be used as alternatives to red blood cell transfusion offer the promise of preserving tissue perfusion and minimizing hypoxic cellular damage, and this promise may soon be fulfilled. Clinical testing of hemoglobin-based oxygen carriers has faced and met challenges involving molecular design, safety, efficacy, and regulatory requirements. Three leading candidates hav...
متن کاملImpact of hemoglobin concentration and affinity for oxygen on tissue oxygenation: the case of hemoglobin-based oxygen carriers.
In patients undergoing exchange-transfusion with hemoglobin (Hb)-based oxygen (O₂) carriers (HBOC), native Hb coexists with newly transfused Hb. The two Hb types share the same arterial and venous PO₂, but their affinities for O₂ vary. A simple spreadsheet model is described aiming at evaluating the contribution of each Hb type to the overall O₂ transport characteristics as a function of the ba...
متن کاملComparison of the Pharmacokinetic Properties of Hemoglobin-Based Oxygen Carriers
Hemoglobin (Hb) is an ideal material for use in the development of an oxygen carrier in view of its innate biological properties. However, the vascular retention of free Hb is too short to permit a full therapeutic effect because Hb is rapidly cleared from the kidney via glomerular filtration or from the liver via the haptogloblin-CD 163 pathway when free Hb is administered in the blood circula...
متن کاملThe affinity of hemoglobin for oxygen.
The delivery of oxygen to the cell depends in good measure upon the affinity with which hemoglobin binds oxygen or releases it from erythrocytes for use by the other cells of the body. The release of oxygen by normal human hemoglobin A, over a range of partial pressures of oxygen, may be represented graphically by the familiar, sigmoid-shaped, oxygen dis-sociation curve. Numerically, the affini...
متن کاملSpecific Oxygen Affinity of Hemoglobin in Elasmobranchs
ERS CHARLES P. EMERSON, M.D. , Boston CLEMENT A. FINCH, M.D., Boston ROBERT S. EVANS, M.D. , San Francisco LAWRENCE E. YOUNG, M.D. , Rochester, N. Y. OLIVER P. JoNas, Pn.D. , Buffalo JEAN P. SOULIER, M.D. , ParIs SOLOMON ESTREN, M.D., New York JAN WALDENSTROM. , M.D. , Upsala, Sweden RAMON M. SUAREZ, San Juan, Puerto Rico HEMOGLOBIN, METHEMOGLOBIN AND BILIRUBIN METABOLISM SPECIFIC OXYGEN AFFINI...
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ژورنال
عنوان ژورنال: Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics
سال: 2008
ISSN: 1570-9639
DOI: 10.1016/j.bbapap.2008.01.001